Highlights

Above

With 3D printing, artificial bones could be printed into unusual shapes like gyroids, making them stronger and more stable.

© Shutterstock

Shaping 3D-printed bones for better implants

5 Mar 2021

Porous metallic bones designed to be 3D-printed in unusual shapes could be the future of permanent orthopedic implants.

Gyroids are oddly shaped objects: their curved geometrical structures contain no straight lines and never self-intersect, and yet they remain infinitely connected. These gyroid structures can also be found in nature, as photonic nanostructures in the wings of the Callophrys rubi butterfly.

The highly curved surfaces in gyroids also make them excellent candidates for artificial bone implants. The only problem? Getting their pore sizes right remains a challenge—if the pores are too big, bone cells cannot attach to the scaffold; if the pores are too small, the transport of nutrients to the bone tissue is hindered.

To enhance the biocompatibility of 3D-printed bone implants, researchers in Singapore designed a heterogeneous gyroid structure that solved both problems: millimeter-scale pores for nutrient and oxygen exchange, and micrometer-scale pores for cell adhesion and growth.

“Biostructural and mechanical compatibility are the most important factors for the success of an artificial implant in the human body,” said Pan Wang, a Scientist at A*STAR’s Singapore Institute of Manufacturing Technology (SIMTech) and the lead author of the study. “In addition, the implants also need to have similar stiffness and strength to bone to avoid stress-shielding effects, which will lead to the loss of surrounding bone mass.”

While searching for an ideal artificial bone implant, the team reviewed an internally developed database for suitable initial gyroid structures. Using a simulation technique called finite element modeling, they then developed modified gyroid 3D lattices with the desired pore size and mechanical properties using detailed visualizations of stress distribution patterns.

Next, the researchers selected a Ti-6Al-4V alloy for their implant material and successfully fabricated five types of gyroid structures by electron beam melting, a type of metal 3D printing. The lattices had variable cell wall thicknesses and pore sizes and possessed a range of Young’s modulus from 8 to 15 GPa and compressive strength from 150 to 250 MPa. These mechanical properties are well within the range observed with human bone, Wang noted.

Introducing numerous pores within the gyroid structures also distributed stress more evenly, allowing the implants to deform more stably and avoid brittle failure. Furthermore, these pores also enhance the biological function of metallic lattices, Wang added. “After implantation, the metallic ‘skeleton’ populated with cells will grow with the femur and its mechanical properties will gradually change to a bone-like one,” he said.

Wang believes that their research findings will support the development of more biocompatible implants as well as further knowledge into lattice design and 3D printing. “Our target is to develop permanent orthopedic implants that can fully eliminate stress shielding and last beyond a patient’s lifetime,” he said.

The A*STAR-affiliated researchers contributing to this research are from the Singapore Institute of Manufacturing Technology (SIMTech).

Want to stay up to date with breakthroughs from A*STAR? Follow us on Twitter and LinkedIn!

References

Wang, P., Li, X., Luo, S., Nai, M.L.S., Ding, J., et al. Additively manufactured heterogeneously porous metallic bone with biostructural functions and bone-like mechanical properties. Journal of Materials Science & Technology 62 173-179 (2021) | article

About the Researcher

Pan Wang is a Scientist II in the Metal & Ceramic Forming Group at A*STAR’s Singapore Institute of Manufacturing Technology (SIMTech). He leads the development of electron beam melting (EBM) process from fundamental research to industrial applications. His research covers the development of high-performance metallic powders for additive manufacturing; design and optimization of new structures for additive manufacturing; promotion of additive manufacturing technology to the industry by overcoming the shortcomings of current technology; and phase transformation and deformation behavior of metastable alloys.

This article was made for A*STAR Research by Wildtype Media Group