Cancer biology

Neutrophils, typically our immune defenders, can paradoxically promote cancer progression when altered in tumours.

New insights into the tumor microenvironment may help researchers stop the growth and spread of cancer to other parts of the body.

A*STAR scientists have identified a microRNA that can potentially be targeted for the treatment of triple-negative breast cancer.

A*STAR scientists have developed a method to measure crucial protein-protein interactions in cancer cells, with implications for drug design and discovery.

A*STAR researchers have turned a bacterial protein into a biosensor that can be used to visualize interactions between proteins.

A better understanding of the way sugar units are attached to the surface proteins of cancer cells may help to improve targeted cancer treatments, A*STAR scientists say.

Bortezomib, a drug that inhibits the ‘waste disposal system’ in animal cells, could be used to suppress cell division in cancer.

A*STAR researchers demonstrate how the expression of genes from alternative gene promoters is associated with lower cancer survival in patients.

By interfering with the production and downstream activity of a molecule called Agrin in tumors, scientists can stop the sprouting of blood vessels that promote cancer progression.

In times of stress, cancer cells move a protein normally found inside the cell to the cell surface, making it accessible to antibodies for immunotherapy.

A*STAR scientists have identified two Epstein-Barr virus strains associated with a high risk of causing nasopharyngeal carcinoma.

Researchers reveal that the buildup of branched-chain amino acids fuels the growth and aggressiveness of liver cancer cells.