Drug resistance

The infection-causing fungus Candida auris repurposes a calcium pump into a drug export system, allowing its survival against a standard treatment.

A new cellular model of colorectal cancer helps identify high-risk subtypes likely to resist standard treatments and proliferate in response.

Drug-resistant malarial parasites form flower-like structures to shield themselves from attack by antimalarial drugs and the immune system.

Scientists discover a potential therapeutic target to tackle a dangerous drug-resistant yeast strain.

Contrary to popular belief, a new A*STAR study shows that HIV mutations are far from random, emerging at specific locations at specific rates.

From expanding the genetic alphabet to uncovering antibiotics hidden in silent genes, A*STAR’s researchers are wielding the tools of synthetic biology to improve our lives in surprising ways.

When combined with low doses of antibiotics, this biodegradable polymer can reduce or even reverse antimicrobial resistance.

A new machine learning technique can predict the dynamics between microbes and therapeutics with unprecedented accuracy.

Cancer cells evade Taxol-induced cell death by downregulating the expression of a protein known as BimEL.

State-of-the-art single-cell RNA sequencing technologies shed light on the mechanisms through which cancer cells become resistant to tumor-treating drugs

Thermal stress elicits genomic changes that can make cancer cells resistant to chemotherapy

By using nanosized charged polymer balls to attack tumors directly rather than carry drugs, researchers have found a way to overcome drug resistance