Genome Institute of Singapore (GIS)
A*STAR scientists have uncovered a novel surface marker that identifies stem cells and potential cancer stem cells in the distal stomach.
A*STAR scientists have identified drug compounds that could potentially eradicate an aggressive form of liver cancer by targeting a metabolic vulnerability induced by the SALL4 oncogene.
Jingmei Li is developing a risk scoring system for breast cancer that could help clinicians formulate better screening programs to catch the disease in its early stages.
A*STAR scientists have created the world’s largest multi-ethnic Asian genetic database to further biomedical research and shed light on the origins of three major ethnic groups in the region.
A*STAR scientists have devised an algorithm for accurately assembling genomes, paving the way for in-depth analysis of microbial communities in the human gut.
A*STAR researchers demonstrate how the expression of genes from alternative gene promoters is associated with lower cancer survival in patients.
A gene variant more common among East Asians is responsible for milder symptoms and better outcomes during hepatitis B infection.
Short- and long-range interactions that give structure to virus genomes also influence virus replication and infectiousness.
Disruption of the methionine cycle in tumor-initiating cells disarms their tumorigenic capabilities, researchers say.
A*STAR scientists have identified two Epstein-Barr virus strains associated with a high risk of causing nasopharyngeal carcinoma.
A platform for rapidly profiling mutations and gene expression offers valuable insights into cancer biology