Genome Institute of Singapore (GIS)

A*STAR scientists have created the world’s largest multi-ethnic Asian genetic database to further biomedical research and shed light on the origins of three major ethnic groups in the region.

A*STAR scientists have devised an algorithm for accurately assembling genomes, paving the way for in-depth analysis of microbial communities in the human gut.

A*STAR researchers demonstrate how the expression of genes from alternative gene promoters is associated with lower cancer survival in patients.

A gene variant more common among East Asians is responsible for milder symptoms and better outcomes during hepatitis B infection.

Short- and long-range interactions that give structure to virus genomes also influence virus replication and infectiousness.

Disruption of the methionine cycle in tumor-initiating cells disarms their tumorigenic capabilities, researchers say.

A*STAR scientists have identified two Epstein-Barr virus strains associated with a high risk of causing nasopharyngeal carcinoma.

A platform for rapidly profiling mutations and gene expression offers valuable insights into cancer biology

State-of-the-art single-cell RNA sequencing technologies shed light on the mechanisms through which cancer cells become resistant to tumor-treating drugs

Thermal stress elicits genomic changes that can make cancer cells resistant to chemotherapy

A deeper understanding of chromosome capping could improve therapies for both cancer and aging

A dual-function protein switch can be tweaked to improve the effectiveness of cellular reprogramming