Human Health and Potential (HHP)

A*STAR researchers develop a deep learning tool to overcome the lack of matched healthy DNA samples when identifying cancer-linked mutations in tumour sequencing data.

The infection-causing fungus Candida auris repurposes a calcium pump into a drug export system, allowing its survival against a standard treatment.

AI-powered analysis of cardiac muscle motion could help identify microvascular obstruction without requiring contrast-enhanced imaging.

Integrating spatial information to the metabolic readouts of liver cancer samples reveals region-specific markers that conventional bulk profiling methods miss.

A*STAR researchers discover a new vaccine target for malaria that could offer more durable protection.

A*STAR researchers showcase the improved potency and safety of a new protective molecule for mRNA vaccines compared to commercial options.

Unlike conventionally destructive RNA extraction techniques, a new gentler RNA sampling platform enables profiling of the same cell samples repeatedly over time.

Researchers pinpoint a specific marker for gastric cancer stem cells and show that eliminating this subpopulation may be a viable approach to more effectively treat stomach cancers.

In lung cancer, tumour-initiating cells harness ketones as an alternative energy source during nutrient stress, but this flexibility also leads to a therapeutic vulnerability.

Shattering a protein “shield” linked to drug resistance could offer clinicians a new weapon against advanced lung cancers.

A molecule found in Aedes mosquito saliva modulates the host body’s immune response during chikungunya infection, highlighting that mosquitoes may be more than just viral carriers.

A novel RNA-based molecular tool offers an innovative way to detect, amplify and respond to genetic signals within cells with unprecedented modularity.