Researcher

Christopher J. Brown is a Principal Investigator at the Institute of Molecular and Cell Biology (IMCB), co-leading the P2ERL (Protein and Peptide Engineering and Research) lab. Over the last 20 years he has carried out his research in Singapore and has had a keen interest in understanding the parameters that underpin macrocyclic peptide cell permeability. This research has been highly collaborative, leading to many beneficial interactions and collaboration within A*STAR (BII, ISCE2) and with external partners (MSD, IPSEN). Brown graduated from the University of Leeds, UK, and obtained an MRes from the University of York, UK. He then carried out his PhD studies in the Structural Biochemistry group at the University of Edinburgh, UK, before leaving for Singapore to work with Sir David Lane. An important focus of his current work is to develop libraries to discover new binding sites using phenotypic screens to nucleate the development of tools for target site validation and hit discovery. For example, discovering novel helical peptide interaction sites that can take advantage of the known ‘rules’ for stapled peptide development, which elicit desirable phenotypic effects.