Gene therapy

A deeper look at nanoparticle design reveals how customised lipid carriers with advanced structures can greatly enhance the delivery of mRNA treatments.

Researchers developed a new method to improve the effectiveness of islet cell transplants, which may offer better treatment options for people with diabetes.

Gene editing holds promise for treating many conditions, but the bacterial origins of RNA-editing enzymes has been found to activate unwanted immune responses in healthy people.

Experimental gene therapy promises a new lease of life for patients with genetic heart disease.

Nuevocor, an A*STAR spin-off company, is designing novel therapies to target the genetic causes of heart diseases, bringing basic research to clinical impact.

Uncovering the molecular mechanisms behind immune system activation could help in future gene therapies

New design guidelines from researchers in Singapore simplify the development of targeted therapies for muscular dystrophy and other diseases

Through a combination of two powerful methodologies, researchers at the A*STAR Institute of Bioengineering and Nanotechnology drive forward promising developments for gene therapy

Adding back a gene that is missing in cells from patients with skin fragility disorders restores the cells’ normal response to stress

Gene therapy restores adaptive immunity in patients with chronic hepatitis B and directs T cells to tumor cells in patients with hepatitis B virus-related hepatocellular carcinoma

Increasing the efficacy and minimizing unwanted side effects of cancer gene therapy has been made possible using a new approach