Genomics

DNA sequencing reveals how breast cancer cells rearrange their genome to create fusion genes for driving tumor development

A high-throughput sequencing strategy allows scientists to follow cancer’s trail of genomic destruction

Variations in three genes can affect the size of the optic disc, a structure in the eye that is larger in individuals with visual dysfunction

A genome-wide RNA interference screen identifies genes that govern the unique properties of human embryonic stem cells

A genome-wide association study identifies genetic factors that increase the risk of meningococcal disease

Cancer geneticists in Singapore seek clinical relevance in large-scale cancer genomics studies

A large-scale genomic analysis yields insights into a cancer that disproportionately affects individuals from southern China

Mammalian genomes display large differences where the regulatory proteins of their embryonic stem cells bind

Genomic technologies developed by A*STAR’s Singapore Immunology Network (SIgN) form the basis for a new vaccine development platform that could pave the way for cost-effective personalized therapy

Elephant sharks display the potential for color vision despite mainly residing in deep waters

Chromosomal looping enables genome-wide ‘remote control’ of transcription, and may help coordinate activity from multiple genes

Findings from an intensive genomic study contradict the conventional explanation—viral mutation—as the cause of dengue fever outbreaks