P53
Turning cancer against itself
18 Nov 2020Exploiting a mutation in a key tumor-fighting protein may provide a new opportunity to treat aggressive lung cancers.
Turning immunotherapy inside out
31 Aug 2020A novel targeting strategy may make pave the way for effective cancer immunotherapy against previously ‘undruggable’ targets.
A stabilizing strategy to keep cancer cells in check
29 Nov 2019Bortezomib, a drug that inhibits the ‘waste disposal system’ in animal cells, could be used to suppress cell division in cancer.
Tapeworm drug targets common vulnerability in tumor cells
17 Mar 2019Drug screen reveals safe, potent, broad-spectrum anticancer compound
Quelling anti-viral responses
29 Nov 2018The Influenza A virus deliberately enhances levels of the human p53 protein to reduce anti-viral gene and protein expression
Getting binding pockets out of hiding
18 Apr 2017Benzene-based
probes highlight two hidden binding sites on an anticancer drug target in a
multidisciplinary strategy
Molecular probes light the way
23 Sep 2014Fluorescent molecular rotors developed by the A*STAR Molecular Engineering Laboratory promise to revolutionize the search for new anticancer drugs
Finding consensus on target genes
3 Jun 2014A panel of p53 variants helps scientists confidently identify genes controlled by the master regulator protein
Keeping bad company
15 Jan 2013Certain mutations cause a cancer-preventing protein to interfere with cellular pathways and actively drive cancer progression
Seeing the light
14 Feb 2012Tagging genomic elements with fluorescent proteins helps to reveal the secrets behind p53 activity
A pause that refreshes
14 Sep 2010Pre-treatment with a cell division-blocking drug protects healthy cells from the devastating effects of chemotherapy
Keeping death in check
19 Jan 2010A small RNA molecule has a big influence on the activity of an important tumor suppressor