Pluripotency

Two proteins maintain embryonic stem cell pluripotency
through different means

A newly discovered hormone has a vital role in survival and differentiation of human embryonic stem cells

Insights into how external mechanical
forces affect stem cell behavior could advance regenerative medicine efforts

Researchers show how human embryonic stem cells maintain the potential to differentiate into almost any cell type, but enter a death pathway if damaged

Cultured human embryonic stem cells given the ‘3iL’ treatment more closely resemble natural stem cells from the developing embryo

A protein called SON ensures proper splicing of proteins to keep embryonic stem cells in a state of self-renewal

A regulatory protein called HEXIM1 induces human pluripotent stem cells to adopt a more specialized cell fate

A location map for a signaling protein identifies key molecular targets in human embryonic stem cells

Pairs of gene-regulating proteins work together to identify their proper binding sites within the genome

A repressor protein that blocks differentiation-specific genes helps maintain stem cells’ ability to develop into any cell type

Skewed X chromosome expression may confound laboratory models of human diseases

Fibroblast growth factor-2 keeps stems cells in their undifferentiated state by activating Wnt signaling