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In revealing
the liver’s ‘weak spot’ for hepatitis B virus replication, A*STAR scientists
are paving the way for new drug development efforts

DNA previously
considered superfluous may provide vital protection against stress and could
even be used in cancer treatment

An enzyme responsible for protecting chromosome ends stimulates tumorigenesis via an unexpected mechanism

Study using a systems biology approach reveals how the transcription factor EVI1 contributes to cancer development and tumor invasion

Zebrafish study reveals a gene regulatory network responsible for establishing and maintaining muscle fiber lineage

Gene regulation may depend more on the synergy of multiple proteins rather than discrete contributions of individual factors

An atlas of embryonic stage-specific gene expression in fish provides insights into a long-standing enigma of the developmental process

Genetically engineered proteins can be used to revert cells back to their undifferentiated state

Efforts to understand a signaling factor’s contradictory behavior reveal a master switch for organ development

Mammalian Rap1 controls transcription through the regulation of NF-κB activity

Mammalian genomes display large differences where the regulatory proteins of their embryonic stem cells bind

Chromosomal looping enables genome-wide ‘remote control’ of transcription, and may help coordinate activity from multiple genes