A*STAR Genome Institute of Singapore (A*STAR GIS)

Researchers reveal how disrupting a key genetic control mechanism can significantly hinder the progression and spread of an aggressive and difficult-to-treat form of breast cancer.

A*STAR researchers identified the mechanism behind how a common gene mutation in kidney cancer impacts chromatin remodelling and drives tumour development, opening up new possibilities for therapeutic interventions.

A new computational tool accurately predicts RNA modifications from sequencing data, allowing researchers to study and develop novel therapies for complex diseases such as cancer.

A new deep learning method outperforms traditional methods for identifying genetic mutations from DNA sequences and can be a valuable tool for improved cancer diagnostics.

Through close collaborations across scientific disciplines, A*STAR drives new discoveries in neurometabolism and its potential therapeutic applications.

Researchers extract insights from large databases of genetic and clinical information in a bid to develop more robust, data-driven breast cancer screening frameworks.

Genomic profiles of the human gut microbiome reveal the hidden impacts of asymptomatic, antibiotic-resistant bacterial infections, as well as potential solutions for their reversal.

With near-real-time genomic monitoring, researchers catch emergent, treatment-evading SARS-CoV-2 mutations in immunocompromised patients with chronic infections.

Unique gene signatures associated with drug-resistant leukaemia paves the way for improved clinical strategies to help these patients.

By exploring the genetic diversity within Escherichia coli bacteria, researchers uncover distinct gene families and a molecular weapon tied to disease-causing strains.

Scientists discover genes encoding colours, scents and bioactive compounds in the genome of Papilionanthe Miss Joaquim, Singapore’s National Flower.

Researchers have discovered a molecular pathway in colorectal cancer cells that leads to uncontrolled division, creating an avenue for more targeted therapies.