A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB)

A cellular ‘stress sensor’ that also modulates metabolism could offer a therapeutic target for diabetes

Insensitivity to a hormone that balances food intake with energy expenditure explains the contradictory effects of different inflammatory conditions on appetite

A large-scale screen reveals how numerous signaling pathways intersect at the cell’s primary protein-processing center

An enzyme responsible for protecting chromosome ends stimulates tumorigenesis via an unexpected mechanism

A protein that represses a critical checkpoint protein for cellular growth helps drive tumor development

Certain mutations cause a cancer-preventing protein to interfere with cellular pathways and actively drive cancer progression

Experiments reveal that the gene controlling the development of an important human organelle hails back to primitive invertebrates

A protein that contributes to cancer vulnerability also plays a surprising role in cardiovascular health and illuminates a promising target pathway for drug treatments for cardiovascular diseases

A study of fruit fly genes reveals how molecules cooperate to induce tumor formation

A signaling receptor that aids bacterial communication may provide a target for reducing virulence without antibiotics

Revelation of the function of a protein complex that controls cell proliferation in fruit fly wings provides insights into tumor growth

New research sheds light on the molecular mechanisms by which a virus contributes to cancer