A*STAR Singapore Immunology Network (A*STAR SIgN)

A deep dive into the skin barrier uncovers the critical role immune cells play in structural reinforcement and wound healing.

In recognition of their research excellence, leadership and impact both locally and globally, ten leading A*STAR researchers have been awarded the A*STAR Distinguished Fellowship and Fellowships.

A new spatial multi-omics tool merges different levels of biological data from the same tissue sample to better differentiate finer details at different health states.

A large-scale gut microbiome study in elderly Singaporeans reveals new insights into the role of our resident microbes in healthy ageing.

Researchers uncovered how specialised stem cells act as building blocks for the esophagus, shaping its development and offering insights into treating related diseases.

A*STAR researchers discovered a potential new treatment for severe eczema by targeting a protein that regulates immune cell activity.

Antibodies in mucous membranes may be key in protecting against SARS-CoV-2 variants, pointing to the need for COVID-19 vaccines that target these antibody responses.

A high-resolution study of SARS-CoV-2 antibodies revealed how they neutralise variants and reduce the impact of spike protein mutations.

Using artificial intelligence techniques, Mai Chan Lau maps the spatial relationships between tumour cells and immune cells to understand their effect on clinical outcomes.

As the immune system ages, our susceptibility to conditions such as cancer increases, prompting researchers to develop advanced experimental models to study these pathways.

Neutrophils, typically our immune defenders, can paradoxically promote cancer progression when altered in tumours.

Researchers find that targeting nerve growth factor in melanomas transforms resistant ‘cold’ tumours into treatable ‘hot’ ones, adding new therapeutic options for challenging skin cancers.