A*STAR Singapore Immunology Network (A*STAR SIgN)
Gluing together layers of molecular insights
29 May 2025A new spatial multi-omics tool merges different levels of biological data from the same tissue sample to better differentiate finer details at different health states.
Microbial neighbours keep golden years shining
22 Apr 2025A large-scale gut microbiome study in elderly Singaporeans reveals new insights into the role of our resident microbes in healthy ageing.
Deconstructing the esophagus cell by cell
3 Mar 2025Researchers uncovered how specialised stem cells act as building blocks for the esophagus, shaping its development and offering insights into treating related diseases.
Taming T cells to douse eczema’s flare
22 Nov 2024A*STAR researchers discovered a potential new treatment for severe eczema by targeting a protein that regulates immune cell activity.
Reinforcing frontline defences against variants
14 Nov 2024Antibodies in mucous membranes may be key in protecting against SARS-CoV-2 variants, pointing to the need for COVID-19 vaccines that target these antibody responses.
Steadying antibodies against variant surges
23 Oct 2024A high-resolution study of SARS-CoV-2 antibodies revealed how they neutralise variants and reduce the impact of spike protein mutations.
Decoding cancer’s molecular dance
5 Sep 2024Using artificial intelligence techniques, Mai Chan Lau maps the spatial relationships between tumour cells and immune cells to understand their effect on clinical outcomes.
Tumours advance as defences ebb
26 Aug 2024As the immune system ages, our susceptibility to conditions such as cancer increases, prompting researchers to develop advanced experimental models to study these pathways.
From immune allies to cancer enemies
12 Aug 2024Neutrophils, typically our immune defenders, can paradoxically promote cancer progression when altered in tumours.
Rewiring cold tumours
2 Aug 2024Researchers find that targeting nerve growth factor in melanomas transforms resistant ‘cold’ tumours into treatable ‘hot’ ones, adding new therapeutic options for challenging skin cancers.
Towards lifelong vitality
15 Jul 2024Through innovative technologies and deep biological insights, A*STAR research institutes and ecosystem partners aim to enhance the healthspan of Asia’s ageing populations.
Growing ‘brains’ put on a show
30 May 2024Lab-grown human brain tissue cultures incorporating immune cells offer never-before-seen insights into the complexity of embryonic brain development.