Structural biology

The detailed structure of a testosterone-regulating enzyme is helping researchers to design better drugs for diseases such as prostate cancer.

Mutations accelerating the degradation of the protein gelsolin are responsible for amyloid plaque buildup in patients suffering from familial amyloidosis, Finnish type.

A*STAR researchers have figured out the detailed structure of a type of protein filament responsible for tethering and moving DNA in bacteria cells.

Leveraging the power of CRISPR-Cas9 to awaken antibiotics from their silent gene clusters

Molecular simulations
reveal why certain cancer therapeutics may bind — or fail to bind — to mutant proteins

Protein structures reveal details of how some bacteria stay in touch with their community

An analysis of capping protein interactions provides insight into how cells move

The proteins that provide essential infrastructure for bacteria exhibit remarkable diversity of structure and function

Two calcium-binding events set major structural rearrangements into motion for an important regulatory protein of human cells