A*STAR Genome Institute of Singapore (A*STAR GIS)

Using improved mouse models for gastric cancer, A*STAR scientists uncover a pool of cancer stem cells key to disease progression.

Understanding the mechanisms behind RNA structure and folding could pave the way for more effective medical treatments, say Yue Wan and Ashley Aw.

Ushering in an era of targeted precision medicine, scientists across A*STAR are propelling the research, commercialisation and implementation of RNA-based therapeutics.

The first open-access database of mononuclear phagocytes, created by A*STAR researchers, provides insight into the biology of these immune cells and their roles in fighting disease.

Nuevocor, an A*STAR spin-off company, is designing novel therapies to target the genetic causes of heart diseases, bringing basic research to clinical impact.

Supported by A*STAR in the early days of their budding careers, scholars recount the experiences that opened the doors to bigger successes from academia to public service.

SARS-CoV-2 genome structures and their interactions with human RNA are shown to be important in virus survival and pathogenicity.

Honored with the President’s Science and Technology Awards, A*STAR researchers are shaping Singapore’s scientific landscape. Here, we spotlight three researchers who have pushed the boundaries in foundational biomedical research, translational engineering efforts and cross-cutting collaborations.

Through the years, A*STAR has always stood at the forefront of science and technology and innovation. Here’s how A*STAR came to be and what it has in store in the upcoming decades.

A new computational method called xPore identifies and estimates the number of specific RNA modifications in biological samples.

Using whole-exome sequencing, scientists have identified a gene likely linked to a common eye disorder that can lead to blindness in the elderly.

Using single-cell sequencing technology, A*STAR scientists have identified a rare population of liver cells susceptible to damage from SARS-CoV-2 infections.