Immunology

A*STAR researchers discovered a potential new treatment for severe eczema by targeting a protein that regulates immune cell activity.

As the immune system ages, our susceptibility to conditions such as cancer increases, prompting researchers to develop advanced experimental models to study these pathways.

Neutrophils, typically our immune defenders, can paradoxically promote cancer progression when altered in tumours.

Researchers find that targeting nerve growth factor in melanomas transforms resistant ‘cold’ tumours into treatable ‘hot’ ones, adding new therapeutic options for challenging skin cancers.

An experimental antibody therapy for solid tumours in adults also shows promise in improving quality of life for paediatric patients.

While the new Omicron XBB COVID-19 subvariant deftly dodges immune defences even in vaccinated individuals, researchers find that mixed mRNA vaccines may offer a vital boost of protection.

Scientists survey how the mpox virus spreads through populations, the immunology of infections and current treatment interventions.

Inactivated COVID-19 vaccines could be an equally potent alternative for people with allergic sensitivities to mRNA-based vaccines.

A new analytical platform reveals signature changes in immune cells of the brain during aging and neurodegenerative conditions such as Alzheimer’s disease.

Vaccinated people affected by COVID-19 variants have different memory B cell responses than their close contacts who remain healthy.

A*STAR researchers discover a mechanism that fires up the metabolism of cancer-killing immune cells, paving the way for future cancer immunotherapies.

A novel molecular mechanism by which a malarial parasite enters host cells may broaden possibilities in malaria vaccine development.