A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB)

The crystal structure of the Dom34–Hbs1 complex reveals how cells recognize and remove defective messenger RNA with stalled elongation through ‘no-go’ decay

Scientists are establishing the basic molecular network of a new player involved in protein secretion and clarifying its regulation in mammalian cells

Mammalian Rap1 controls transcription through the regulation of NF-κB activity

Discovery of the mechanism regulating the expression of an enzyme implicated in human cancer could open new avenues for treatment

A previously unidentified bacterial protein variant gums up the gears of a last-resort cellular suicide mechanism

Pre-treatment with a cell division-blocking drug protects healthy cells from the devastating effects of chemotherapy

Mutations in a structural protein sabotage signaling pathways that control skin cell survival

An analysis of capping protein interactions provides insight into how cells move

Disrupted cellular transport of sugar-coating enzymes may cause cancers to spread

The interaction points between proteins regulating cell growth could offer promising future targets for fighting cancer

The proteins that provide essential infrastructure for bacteria exhibit remarkable diversity of structure and function

A protein primarily active in the nucleus also operates within the cytoplasm to orchestrate cell movement