Highlights

In brief

Researchers find notable differences in macronutrient digestibility and amino acid composition between animal- and plant-based meats, offering insights for improving alternative protein products.

Photo by Lukas Tennie | Unsplash

Digesting the difference between plant and animal proteins

25 Aug 2025

A study on how animal meats and their plant-based alternatives are digested uncover key nutritional differences with implications for future food innovation.

With meat and seafood consumption in Asia expected to rise by 33 percent by 2030, the search for sustainable alternatives is gaining urgency. From climate-conscious consumers to health-focused eaters, more people across the region are turning to plant-based options that replicate the taste and texture of familiar favourites.

Though plant-based alternatives are designed to resemble animal meats in taste and appearance, they often differ in their nutritional content and benefits. “Much of the current focus in developing alternative meat products has been on ‘neck up’ aspects such as taste and texture. But there’s still a major gap in understanding their effects ‘neck down’—that is, how they impact the body from a nutritional perspective,” said Caleb Ong, a Research Officer at the A*STAR Singapore Institute of Food and Biotechnology Innovation (A*STAR SIFBI).

Understanding whether alternative proteins can offer comparable nutritional benefits to animal-based protein is critical for long-term health and dietary planning. Ong, alongside Senior Scientist Jie Hong Chiang and their team at A*STAR SIFBI, set out to assess the nutritional quality of both conventional and plant-based versions of popular meat products, including luncheon meat, chicken fillets and fish fingers.

“It wasn’t just about measuring the nutrient content—we wanted to translate these data into meaningful health comparisons, uncovering how these plant-based proteins can contribute to health outcomes relative to animal meat,” said Ong.

Using an established in vitro static digestion protocol (INFOGEST), which simulates human digestion, the team evaluated how each product was broken down by the body. The team found that the animal-based products generally had higher protein digestibility, greater levels of essential amino acids and superior overall protein quality than the alternative meat samples.

Plant-based products, while rich in dietary fibres and complex protein matrices, presented lower digestibility due to their structure—limiting enzyme access to proteins and lipids.

According to the researchers, reduced protein digestibility could result in inadequate absorption of important amino acids required for muscle function, immune response and metabolic health. Similarly, lower lipid digestibility could limit the uptake of essential fatty acids that support neurological health, regulate inflammation and maintain cardiovascular function.

“While alternative proteins present a promising and sustainable option, our findings suggest that their nutritional performance still lags behind that of animal-based proteins in several key areas,” said Ong.

The team’s next phase involves investigating the underlying factors that limit the nutrient bioaccessibility in alternative meats, such as specific protein structures that resist enzymatic digestion. They also aim to explore novel processing techniques to improve nutrient release and develop strategies to enhance nutritional quality.

“Continued innovation is needed to close these nutritional gaps and ensure that alternative protein products are truly complete and functional replacements for their animal-based counterparts,” said Ong. “The goal is to boost nutrient accessibility without compromising the sensory qualities that drive consumer acceptance.”

The A*STAR-affiliated researchers contributing to this research are from the A*STAR Singapore Institute of Food and Biotechnology Innovation (A*STAR SIFBI) and A*STAR Bioprocessing Technology Institute (A*STAR BTI).

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References

Ong, K.S., Lim, P.Y., Ng, F.S.K., Sim, H.Y., Chiang, J.H., et al. A comparative analysis of macronutrient digestibility in animal and alternative meat products for the Asian market. Journal of Food Composition and Analysis 139, 107171 (2025). | article

About the Researchers

Caleb Ong is a Research Officer of the Nutrition & Dietary Health (NDH) division at the A*STAR Singapore Institute of Food and Biotechnology Innovation (A*STAR SIFBI). His research focuses on understanding the digestive behaviour and functional outcomes of novel protein ingredients, with the aim of improving their nutritional performance to better match or exceed that of animal proteins. His work plays a vital role in bridging nutritional science and food innovation, ensuring that emerging protein technologies are physiologically effective and suitable for human health.
Jie Hong Chiang is a Senior Scientist at the Food & Sensory Science (FSS) division at A*STAR SIFBI, driven by the challenge of creating sustainable and delicious plant-based meat alternatives. A key area of his research expertise lies in leveraging plant-based ingredients to replicate the sensory experience of meat, catering to the ever-growing global demand for sustainable protein sources. Chiang’s commitment to innovation is evident in his role as Principal Investigator for the Singapore Food Story R&D programme on Future Foods: Alternative Proteins IAF-PP grant.

This article was made for A*STAR Research by Wildtype Media Group